Nicotinamide riboside (NR) is a form of vitamin B3 that has been found to effectively increase NAD+ levels in cells. Here's a simplified explanation of how NR helps replenish NAD+:

Think of NR as a superhero sidekick for NAD+. When you consume NR, it acts as a special ingredient that your body can easily convert into NAD+. It's like giving your body a secret code to produce more of this essential coenzyme. Once inside your cells, NR undergoes a series of chemical reactions that transform it into NAD+. This newly formed NAD+ then goes to work, playing its crucial role in various cellular processes. By providing your body with NR, you're giving it the building blocks it needs to boost NAD+ levels and support all the important functions that NAD+ is involved in. It's like a natural and efficient way to give your cells a helping hand in producing more NAD+.

The decline of NAD+ levels in the body over time can be attributed to a variety of factors. Here's a simplified explanation:

Think of NAD+ as a limited resource that diminishes as you age. One reason for the decline is that the body's ability to produce NAD+ decreases with time. The enzymes responsible for NAD+ synthesis may become less efficient or decline in number as we grow older. Additionally, various lifestyle factors, such as poor diet, lack of exercise, and excessive stress, can also contribute to the reduction of NAD+ levels.

Another culprit is an enzyme called CD38. As we age, CD38 tends to become more active, consuming NAD+ and breaking it down. This increased CD38 activity further depletes the available NAD+ in our cells.

Furthermore, environmental factors, such as exposure to toxins or UV radiation, can cause DNA damage. When DNA is damaged, NAD+ is consumed in the repair process, leading to its gradual depletion.

Overall, a combination of natural aging processes, lifestyle choices, and environmental factors can contribute to the loss of NAD+ in the body over time. This decline in NAD+ levels can have implications for various cellular processes and may impact overall health and well-being.